翻訳と辞書 Words near each other ・ Phosphoric monoester hydrolases ・ Phosphorine ・ Phosphoadenylyl-sulfate reductase (thioredoxin) ・ Phosphoadenylylsulfatase ・ Phosphoamidase ・ Phosphoamino acid analysis ・ Phosphocarrier protein ・ Phosphocholine ・ Phosphocreatine ・ Phosphodiester bond ・ Phosphodiesterase ・ Phosphodiesterase 2 ・ Phosphodiesterase 3 ・ Phosphodiesterase 4 ・ Phosphodiesterase I ・ Phosphodiesterase inhibitor ・ Phosphodiesterase-4 inhibitor ・ Phosphoenolpyruvate carboxykinase ・ Phosphoenolpyruvate carboxykinase (ATP) ・ Phosphoenolpyruvate carboxykinase (diphosphate) ・ Phosphoenolpyruvate carboxylase ・ Phosphoenolpyruvate mutase ・ Phosphoenolpyruvate phosphatase ・ Phosphoenolpyruvate—glycerone phosphotransferase ・ Phosphoenolpyruvate—protein phosphotransferase ・ Phosphoenolpyruvic acid ・ Phosphoenolpyruvic carboxykinase ・ Phosphoenolpyruvic carboxylase ・ Phosphoethanolamine N-methyltransferase ・ Phosphoethanolamine/phosphocholine phosphatase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Phosphodiesterase inhibitor ： ウィキペディア英語版 Phosphodiesterase inhibitor A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). ==History== The different forms or subtypes of phosphodiesterase were initially isolated from rat brains by Uzunov and Weiss in 1972〔Uzunov, P. and Weiss, B.: Separation of multiple molecular forms of cyclic adenosine 3',5'-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis" ''Biochim. Biophys. Acta'' 284:220-226, 1972. doi:10.1016/0005-2744(72)90060-5.〕 and were soon afterward shown to be selectively inhibited in the brain and in other tissues by a variety of drugs.〔Weiss, B.: Differential activation and inhibition of the multiple forms of cyclic nucleotide phosphodiesterase. ''Adv. Cycl. Nucl. Res.'' 5:195-211, 1975.〕〔Fertel, R. and Weiss, B.: Properties and drug responsiveness of cyclic nucleotide phosphodiesterases of rat lung" ''Mol. Pharmacol'' 12:678-687, 1976.〕 The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait.〔Weiss, B. and Hait, W.N.: Selective cyclic nucleotide phosphodiesterase inhibitors as potential therapeutic agents. ''Ann. Rev. Pharmacol. Toxicol.'' 17:441-477, 1977.〕 This prediction meanwhile has proved to be true in a variety of fields. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Phosphodiesterase inhibitor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.